Recent research has uncovered a possible mechanism of the cause of allergic-like symptoms such as asthma, migraines, and sick building syndrome when a person is exposed to Volatile Organic Chemicals(VOC) such as hydrocarbons, perfumes, fertilizers, and cigarette smoke. This mechanism is not based on an allergy model but on a stressed nervous system model.
In a previous blog entry, the protein Nerve Growth Factor(NGF) was discussed as an internally synthesized protein that causes the nervous system to proliferate hypersensitive nerve endings and causes sensory cells, when irritated, to produce an inflammatory chemical called Substance P. Substance P causes increased pain, smooth muscle contractions, acute inflammation, induces mast cells to release histamine and modulates the production of antibodies associated with allergies. NGF is also synthesizes when the autonomic nervous system is stressed.
The proposed mechanism of chemical sensitivity:
1) Stress increases the production of NGF.
2) NGF causes sensory nerves to proliferate and become hypersensitive.
3) VOC cause autonomic system stress and attach to chemical irritant receptors on hypersensitive sensory nerves.
4) Stimulated sensory nerves release Substance P causing inflammation, stress, and the release of histamine by mast cells.
This is the important part. A chemical called Neutral Neuropeptidase(NEP) degrades Substance P. When released, Substance P causes inflammation and allergy-like symptoms. But when NEP is present, the quantity of Substance P decreases resulting in less inflammation and less stress.
In addition to Volatile Organic Chemicals irritating sensory nerves, VOC also suppresses NEP. The suppression of NEP prolongs the life of Substance P and inflammation. Allergy-like symptoms arise without involving antibodies. Allergy-like symptoms appear due to a hypersensitive, stressed nervous system.
The BAX3000 works by reducing the stress and hypersensitivity of nerves when exposed to VOC. The BAX3000 creates a positive association between VOC and stress-reducing endorphins. The new association reduces stress and stops the following release of inflammatory chemicals.
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